Diazochemistry

Short historical review
(full version: V.A. Nikolaev, L.L. Rodina, Chemistry and computer modeling. Butlerov’s reviews 2001, #4 (in Russian), and J.J. Medvedev, V.A. Nikolaev, Russian Chemical Reviews 84 (7), p. 737 – 757 (2015, english))

Aliphatic diazo compounds are of great importance in organic synthesis. Actually, almost every class of organic compounds can be prepared using diazo compounds. A great impulse to the development of the chemistry of diazo compounds was given by the broad application of catalytic methods for selective transformations of diazo compounds into various target molecules. Metallocarbenes (carbenoids) are key intermediates in these reactions. These compounds are of major significance in synthetic and theoretical organic chemistry. At the present time, the stress is given to the promising area of research in the chemistry of catalytic transformations of diazo compounds dealing with multicomponent processes. These reactions of diazo compounds are initiated by transition metal complexes in the presence of several reagents and enable a multistage process to be carried out actually as a one-pot procedure with high diastereo- and enantioselectivity.


The results of recent studies show that Rh II -catalyzed multicomponent reactions of aliphatic diazo compounds provide a powerful tool for the directed organic synthesis. These reactions allow researchers to perform the three- or four-component processes as one-pot procedures and prepare complex organic molecules, biologically active and natural compounds with high diastereo- and enantioselectivity. Noteworthy are successful attempts to use co-catalysts in order to increase the efficiency and stereoselectivity of the transformations under consideration. This is a new area of the chemistry of metal complex-catalyzed reactions of diazo compounds and an efficient tool, which can be employed to change the reaction pathway and substantially increase the selectivity
of multicomponent processes. Although the reactions of diazo compounds catalyzed by transition metal complexes have been extensively studied
for many years, this area of the chemistry of diazo compounds is undoubtedly far from being exhausted and new discoveries will be expected in the future.

Recent achievements of our group in diazo chemistry field

Dmitrii Semenok’s recent papers RESEARCHGATE (Dmitrii V. Semenok)

Jury Medvedev’s recent papers RESEARCHGATE (Jury J. Medvedev)

Olesia Galkina’s recent papers RESEARCHGATE (Olesia S. Galkina)

Valerij Nikolaev’s recent papers RESEARCHGATE (Valerij A. Nikolaev)